Amandola is an Italian municipality of 3 401 inhabitants in the province of Fermo in the region of Marche, Italy. Amandola takes its name from the almond tree in Italian "Mandorlo" which was once many in the city. The city stands on the slopes of Mount Amandola. The town was founded in 1248 by the union of the three castles that were respectively on three different hills: Agello, Castel Leone, and Marrubbione which formed a free city.

Amandola is known for the black and white truffles and various festivals are held just for them.

Amandola is one of the 18 Italian municipalities located within the Monti Sibillini National Park in the Apennines.

Amandola was damaged by the earthquake in Central Italy (near Amatrice) on 24 August 2016.